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[Intrauterine nutrition]

T Henriksen1, B Lande, T Clausen

  • 1Institutt for ernaeringsforskning, Blindern, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|October 7, 1998
PubMed
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Intrauterine nutrition significantly impacts long-term health. Nutritional deficits during fetal development can permanently alter gene expression, increasing risks for later-life diseases like cardiovascular disease and diabetes.

Area of Science:

  • Developmental Biology
  • Nutritional Science
  • Epigenetics

Context:

  • Growing interest in fetal and intrauterine nutrition.
  • Association between being born small for gestational age and increased risk of cardiovascular disease and diabetes.
  • Discovery of direct influence of nutritional factors on gene activity.

Purpose:

  • To explore the impact of fetal nutrition on gene expression and long-term health outcomes.
  • To understand the causes and consequences of intrauterine malnutrition.
  • To highlight the significance of fetal nutrition for lifelong health.

Summary:

  • Nutritional inadequacies during fetal development can permanently alter gene expression.
  • Causes of intrauterine malnutrition include poor maternal diet, placental insufficiency, and impaired fetal nutrient utilization.

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  • Consequences include intrauterine growth retardation, congenital malformations, neurological dysfunction, and increased susceptibility to diseases later in life.
  • Impact:

    • Altered gene expression due to fetal malnutrition can modify susceptibility to perinatal complications and adult diseases.
    • Fetal malnutrition is a significant determinant of health throughout an individual's life.
    • Understanding fetal nutrition is crucial for preventing chronic diseases and improving lifelong health outcomes.