Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Class-directed structure determination: foundation for a protein structure initiative

T C Terwilliger1, G Waldo, T S Peat

  • 1Structural Biology Group, Los Alamos National Laboratory, New Mexico 87545, USA. terwilliger@lanl.gov

Protein Science : a Publication of the Protein Society
|October 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time to operative care for breast cancer in the Cape Metro West region.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2025
Same author

Time to regional surgical care in rural South Africa.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2025
Same author

Validation of a diagnostic support tool for early recognition of cervical arterial dissection in primary care.

Clinical neurology and neurosurgery·2024
Same author

An analysis of referral patterns of traumatic brain injury at Groote Schuur Hospital Trauma Centre.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Stereotactic Magnetic Resonance-Guided Daily Adaptive SABR (SMART) for Localised Non-Metastatic Pancreatic Cancer: First Reported Clinical Outcomes From the UK.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

[Prevalence of medicare antiviral drugs use and related factors in HIV-infected people in Ningbo].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2024

Protein structure determination is evolving from individual analysis to class-directed studies. This shift enables efficient analysis of protein families for biotechnology and fundamental research.

Area of Science:

  • Structural Biology
  • Genomics
  • Biotechnology

Background:

  • Advances in genome sequencing and protein structure determination methods are transforming research.
  • Traditional methods focus on individual protein structures, which is time-consuming for large-scale studies.

Purpose of the Study:

  • To introduce a paradigm shift towards class-directed protein structure analysis.
  • To lay the foundation for a comprehensive protein structure initiative.

Main Methods:

  • Leveraging complete genome sequences.
  • Employing rapid protein structure determination techniques.
  • Selecting representative proteins from targeted classes for structural analysis.

Main Results:

Related Experiment Videos

  • Individual protein structure determination will be complemented by class-based approaches.
  • A strategy for analyzing entire protein families through representative structures is proposed.

Conclusions:

  • Class-directed structure analysis offers a more efficient approach to understanding protein families.
  • This strategy supports advancements in biotechnology and fundamental protein function research.