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Methylenetetrahydrofolate-reductase gene C677T variant and kidney-transplant survival

O Liangos1, R Kreutz, J Beige

  • 1Department of Internal Medicine, Universitätsklinikum Benjamin Franklin, Berlin, Germany.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|October 7, 1998
PubMed

Insights

The methylenetetrahydrofolate reductase (MTHFR) C677T gene variant does not significantly impact kidney transplant survival. This study found no link between MTHFR genotype and allograft survival rates in renal transplant patients.

Area of Science:

  • Nephrology
  • Genetics
  • Transplantation Immunology

Background:

  • Hyperhomocysteinemia is a known risk factor for atherosclerosis and is prevalent in patients undergoing hemodialysis and renal transplantation.
  • Atherosclerotic lesions in hyperhomocysteinemia share similarities with chronic allograft injury.
  • The methylenetetrahydrofolate reductase (MTHFR) C677T gene variant is associated with elevated homocysteine levels in renal failure patients.

Purpose of the Study:

  • To investigate the hypothesis that the MTHFR C677T gene variant influences renal allograft survival.
  • To determine if MTHFR genotype is a significant determinant of long-term kidney transplant success.

Main Methods:

  • Prospective DNA collection from 336 renal transplant recipients and their donors.
  • Analysis of patient and allograft survival over 36 months via blinded record review.
  • Genotyping for MTHFR C677T using PCR-RFLP and survival analysis using Kaplan-Meier and log-rank tests.

Main Results:

  • The MTHFR C677T allele frequency was consistent across recipients, donors, and long-term survivors.
  • Kaplan-Meier analysis showed similar 36-month allograft survival rates among different MTHFR genotype groups (CC, CT, TT).
  • Other potential risk factors were evenly distributed across genotype groups.

Conclusions:

  • The findings do not support the hypothesis that the MTHFR C677T gene variant is a significant determinant of renal transplant survival.
  • The MTHFR C677T genotype does not appear to be a critical factor in predicting kidney allograft outcomes.
Abstract

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