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Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase
W J McKinstry1, A J Oakley, J Rossjohn
1The Ian Potter Foundation Protein Crystallography Laboratory, St Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.
Acta Crystallographica. Section D, Biological Crystallography
|October 8, 1998
Abstract:
Human theta-class glutathione S-transferases (GST's) appear to play a critical role in the metabolism of a variety of environmental pollutants but in some cases the products of the reaction are carcinogenic. Crystals of a human theta-class GST, namely hGSTT2-2, have been grown from polyethylene glycol by the hanging-drop vapour-diffusion method. The crystals belong to the trigonal space group P3121 with cell dimensions of a = b = 94.0 and c = 120.5 A. They contain two monomers in the asymmetric unit and diffract to 3.0 A resolution.