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Potential role for growth hormone in human lactation insufficiency
S R Milsom1, D L Rabone, A J Gunn
1Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand. s.milsom@auckland.ac.nz
Hormone Research
|October 8, 1998
Summary
This study found that recombinant human growth hormone (rhGH) therapy significantly improved milk production in mothers experiencing early postpartum lactation insufficiency. Moderate doses of rhGH effectively boosted galactopoiesis, aiding breastfeeding mothers.
Area of Science:
- Endocrinology
- Lactation Physiology
- Reproductive Medicine
Background:
- Idiopathic lactation insufficiency is a common challenge for mothers in the early postpartum period.
- Enhancing galactopoiesis, the maintenance of milk production, is crucial for successful breastfeeding.
- Recombinant human growth hormone (rhGH) has potential therapeutic applications in lactation support.
Purpose of the Study:
- To evaluate the galactopoietic effect of different doses of rhGH in mothers with early postpartum idiopathic lactation insufficiency.
- To determine the optimal dosage of rhGH for improving milk production.
Main Methods:
- A preliminary, randomized, single-blind trial was conducted.
- 24 mothers received one of three doses of rhGH (0.05, 0.1, or 0.2 IU/kg/day) for 7 days.
- 24-hour milk production was measured before and after therapy.
Main Results:
- The group receiving the highest dose (0.2 IU/kg/day) showed a significant increase in milk production (36.0 +/- 12.6%).
- Lower doses of rhGH resulted in a less pronounced increase (4.7 +/- 9.7%, p < 0.04).
Conclusions:
- Moderate dose rhGH therapy can effectively improve galactopoiesis in mothers with lactation insufficiency.
- These findings suggest rhGH as a potential treatment to enhance milk production in specific postpartum scenarios.