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Clinical and metabolic studies in children of diabetic-mothers
Insights
Children born to diabetic mothers face risks. Metabolic follow-up studies reveal early diabetic signs like insulin-high response and abnormal growth hormone reactions in these children.
Area of Science:
- Pediatrics
- Endocrinology
- Perinatology
Background:
- Children of diabetic mothers represent a high-risk group.
- Pregnancy complications like metabolic control, toxemia, and UTIs significantly impact perinatal outcomes and child development.
- Long-term developmental outcomes in these children require thorough evaluation.
Purpose of the Study:
- To assess the diabetogenic risk in children of diabetic mothers.
- To identify early indicators of diabetes in this high-risk population.
- To evaluate the influence of maternal diabetes on child development.
Main Methods:
- Metabolic follow-up studies were conducted on children of diabetic mothers.
- Intravenous glucose infusion tests were performed.
- Oral glucose tolerance tests (oGTT) were administered.
- Growth hormone response to glucose load was assessed.
Main Results:
- 25% showed insulin-high response post-intravenous glucose; 28% post-oral glucose, without impaired carbohydrate tolerance.
- 17% exhibited paradoxical growth hormone reactions.
- Abnormal results were observed in 18% for oGTT and 8% for glucose infusion tests.
Conclusions:
- Insulin-high response and paradoxical growth hormone reactions may serve as early diabetic signs in children of diabetic mothers.
- These findings highlight the need for early metabolic screening in this population.
- Maternal diabetes quality significantly affects child development outcomes.
Abstract:
Children of diabetic mothers are a high-risk group. The perinatal mortality and the malformation frequency of the newborns as well as the psychosomatic, somatic and speech development during childhood until the age of 15 were statistically significantly influenced by quality of metabolic compensation, toxaemia and urinary tract infections during pregnancy. To evaluate the diabetogenic risk in children of diabetic mothers metabolic follow-up studies were performed. A statistically significant insulin-high-response without disturbed carbohydrate tolerance was seen in 25% after intravenous glucose infusion and in 28% after oral glucose load. 17% exhibited a paradoxical growth hormone reaction, while the intravenous glucose tolerance and the insulin secretion was in the normal range. Both symptoms could be early diabetic signs in children of diabetic mothers. The oGTT had pathological results in 18% and the glucose infusion test in 8%.