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[Autoimmune hepatitis induced by fibrates]

N Ganne-Carrié1, A de Leusse, C Guettier

  • 1Service d'Hépato-Gastroentérologie, Hôpital Jean-Verdier, Bondy.

Gastroenterologie Clinique Et Biologique
|October 8, 1998
PubMed
Summary
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Fibrate medications can cause chronic hepatitis with auto-antibodies. Discontinuing fibrates leads to recovery, sometimes requiring immunosuppression for autoimmune liver disease.

Area of Science:

  • Hepatology
  • Immunology
  • Pharmacology

Background:

  • Long-term fibrate therapy is associated with potential liver injury.
  • Fibrates may induce chronic hepatitis with auto-antibody production.

Purpose of the Study:

  • To characterize the clinical, biological, and histological features of fibrate-induced chronic hepatitis.
  • To evaluate the outcomes of patients with this condition.

Main Methods:

  • Retrospective analysis of 5 patients with fibrate-induced chronic hepatitis.
  • Assessment of clinical data, laboratory results, liver biopsies, and patient outcomes.

Main Results:

  • Patients presented with elevated aminotransferases, hypergammaglobulinemia, and anti-nuclear antibodies.

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  • Liver biopsies showed lymphoplasmacytic infiltrate, hepatocellular necrosis, and in some cases, cirrhosis.
  • Discontinuation of fibrates resulted in normalization of liver enzymes, with or without immunosuppressive therapy.

    • Conclusions:

    • Fibrates can trigger a chronic liver disease mimicking autoimmune hepatitis.
    • Cessation of fibrate therapy is crucial for disease resolution.
    • This drug-induced liver injury is reversible upon drug withdrawal.