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Related Experiment Videos

Minocycline-associated tooth staining

M A Dodd1, E J Dole, W G Troutman

  • 1Presbyterian Healthcare Services, Albuquerque, NM, USA.

The Annals of Pharmacotherapy
|October 8, 1998
PubMed
Summary
This summary is machine-generated.

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Minocycline treatment for arthritis can cause tooth discoloration in adults. This staining resolved after discontinuing the medication, highlighting an important adverse drug reaction.

Area of Science:

  • Pharmacology
  • Dermatology
  • Odontology

Background:

  • Minocycline, a tetracycline derivative, is increasingly used for adult arthritis.
  • Adverse effects include pigmentation of skin, nails, and bone.

Observation:

  • A 68-year-old woman developed blue-black tooth discoloration after 4 months of minocycline therapy.
  • The discoloration was resistant to dental treatment while minocycline was ongoing.

Findings:

  • Tooth discoloration resolved completely within one month of minocycline discontinuation.
  • This contrasts with the persistent nature of minocycline-induced pigmentation in other tissues.

Implications:

  • Clinicians should consider minocycline-induced tooth discoloration as a potential adverse effect in adult patients.

Related Experiment Videos

  • Awareness of this reaction is crucial given the expanding use of minocycline in adult rheumatological conditions.