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Related Experiment Videos

Isoniazid-induced psychosis

A O Alao1, J C Yolles

  • 1Department of Psychiatry, State University of New York Health Science Center, Syracuse, USA.

The Annals of Pharmacotherapy
|October 8, 1998
PubMed
Summary
This summary is machine-generated.

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Isoniazid, a tuberculosis drug, may cause psychosis. This case highlights the importance of recognizing this adverse effect, especially as tuberculosis cases rise.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Infectious Diseases

Background:

  • Tuberculosis treatment often involves isoniazid.
  • Isoniazid prophylaxis is used for latent tuberculosis infection.
  • Psychiatric adverse effects of isoniazid are rare but significant.

Observation:

  • A 31-year-old woman developed psychosis during isoniazid prophylaxis.
  • Symptoms included psychotic features without prior psychiatric history.
  • Psychosis resolved with isoniazid discontinuation and olanzapine treatment.

Findings:

  • Isoniazid can induce psychosis, a serious adverse effect.
  • Pyridoxine deficiency may contribute to isoniazid-induced psychosis.
  • Urinary tryptophan metabolites may indicate pyridoxine deficiency.

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Implications:

  • Clinicians must consider isoniazid-induced psychosis in patients presenting with new-onset psychotic symptoms.
  • Awareness of this potential adverse effect is crucial for effective tuberculosis management.
  • Early recognition and intervention can lead to complete recovery.