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Succinate accumulation in man during exercise

P W Hochachka, R H Dressendorfer

    European Journal of Applied Physiology and Occupational Physiology
    |September 23, 1976
    PubMed
    Summary
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    Succinate, a Krebs cycle component, accumulates in human blood during intense exercise and breath-hold dives. This suggests amino acid breakdown contributes to anaerobic energy production, supplementing glycolysis.

    Area of Science:

    • Exercise Physiology
    • Biochemistry

    Background:

    • Succinate, a Krebs cycle intermediate, accumulates in diving vertebrates during breath-hold dives.
    • This accumulation is hypothesized to stem from amino acid catabolism.

    Purpose of the Study:

    • To investigate succinate accumulation in humans during physical activity with anaerobic energy demands.
    • To explore the role of amino acid catabolism in human anaerobic energy production.

    Main Methods:

    • An endurance athlete performed apneic underwater ergometry and treadmill running to exhaustion.
    • Venous blood samples were analyzed for succinate, alanine, lactate, and pyruvate levels before and during exercise.

    Main Results:

    • Venous succinate levels significantly increased during both breath-hold dives (42 to 125 M X 10(-6)) and maximal treadmill running (42 to 93 M X 10(-6)).

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  • Elevated levels of alanine, lactate, and pyruvate were observed during both exercise types.
  • Confirms succinate accumulation in humans during strenuous activity.

    • Conclusions:

    • Succinate accumulation occurs in humans during exercise requiring anaerobic energy contribution.
    • Amino acid catabolism may serve as an additional anaerobic energy source beyond glycolysis.
    • Further research is needed to quantify the significance of this metabolic pathway.