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Updated: Aug 10, 2026
09:02
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Lumbar intervertebral disc involvement in chronic lymphocytic leukemia. A case report
T U Jiya1, B J Van Royen, S Sugihara
1Department of Orthopaedic Surgery, Free University Hospital, Amsterdam, The Netherlands.
Spine
|October 8, 1998
Summary
This study reports a rare case of chronic lymphocytic leukemia (CLL) affecting an intervertebral disc, presenting diagnostic challenges. Early consideration of CLL is crucial for patients with back pain and neurological symptoms.
Area of Science:
- Oncology
- Hematology
- Spinal Surgery
Background:
- Chronic lymphocytic leukemia (CLL) typically affects lymphoid organs and bone marrow.
- Spinal involvement in CLL is uncommon, with few reported cases of extradural masses causing spinal cord compression.
- Intervertebral disc involvement by CLL has not been previously documented.
Observation:
- A patient with a history of CLL presented with symptoms suggestive of spinal pathology.
- Imaging revealed vertebral collapse and intervertebral disc destruction at L2-L3 with dural compression.
- Histological examination confirmed leukemic cell infiltration of the intervertebral disc.
Findings:
- The case demonstrates a novel presentation of CLL with discovertebral involvement.
- Treatment involved radiotherapy, surgical resection, and spinal stabilization.
- The patient achieved remission and full mobilization 20 months post-treatment.
Implications:
- Intervertebral disc involvement should be considered in CLL patients with back pain and neurological deficits.
- Distinguishing CLL disc infiltration from infectious spondylodiscitis can be challenging.
- Histopathological confirmation is essential for accurate diagnosis and management.
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