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Impaired ventilatory function and elevated insulin levels in nondiabetic males: the Normative Aging Study
R Lazarus1, D Sparrow, S T Weiss
1Dept of Public Health and Community Medicine, Faculty of Medicine, University of Sydney, Australia.
The European Respiratory Journal
|October 8, 1998
Summary
Lower lung function, measured by forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), is linked to insulin resistance in nondiabetic men. This suggests insulin resistance may explain the connection between poor lung function and heart disease risk.
Area of Science:
- Cardiology
- Pulmonology
- Metabolic Health
Background:
- Lower baseline ventilatory function is linked to higher cardiovascular mortality risk.
- Increased coronary heart disease risk is associated with elevated serum insulin levels.
Purpose of the Study:
- To investigate the relationship between ventilatory function and indirect measures of insulin resistance in nondiabetic males.
- To explore potential mechanisms linking impaired lung function to cardiovascular mortality.
Main Methods:
- Cross-sectional analysis of 922 nondiabetic participants from the Normative Aging Study.
- Multiple linear regression models adjusted for confounders (age, BMI, physical activity, etc.).
- Assessment of ventilatory function (FVC, FEV1) against insulin indicators (fasting insulin, FIRI).
Main Results:
- Fasting insulin and the fasting insulin resistance index (FIRI) were negatively correlated with FVC and FEV1 (p<0.001).
- These associations remained significant after adjusting for multiple confounders.
- Negative cross-sectional associations were observed between ventilatory function and insulin resistance measures.
Conclusions:
- Insulin resistance may contribute to the association between impaired ventilatory function and cardiovascular mortality.
- Further research is needed to elucidate the mechanisms underlying this relationship.