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Echocardiographic assessment of left and right ventricular diastolic functions in children with dilated
F Alehan1, S Ozkutlu, D Alehan
1Department of Pediatrics, Hacettepe University, Faculty of Medicine, Ankara.
Insights
Pediatric dilated cardiomyopathy impairs diastolic function in both the left and right ventricles. Echocardiography revealed abnormal relaxation patterns and reduced filling velocities in affected children compared to controls.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Echocardiography
Background:
- Dilated cardiomyopathy (DCM) is a serious condition affecting heart muscle.
- Diastolic dysfunction, impacting the heart's relaxation and filling, is a key concern in pediatric DCM.
Purpose of the Study:
- To evaluate left and right ventricular diastolic functions in children with DCM.
- To compare diastolic function parameters between children with DCM and healthy controls.
Main Methods:
- Pulsed Doppler echocardiography was used to assess diastolic function.
- 16 children with DCM and 20 healthy children were included in the study.
Main Results:
- Children with DCM showed impaired left ventricular diastolic function, including abnormal relaxation, lower peak early filling velocities, and prolonged isovolumic relaxation time.
- Right ventricular diastolic filling was also impaired in the DCM group, with decreased peak early filling velocities and increased isovolumic relaxation time.
- Significant differences (p < 0.05) were observed for multiple diastolic parameters between the DCM and control groups.
Conclusions:
- Diastolic dysfunction is prevalent in both left and right ventricles of children with dilated cardiomyopathy.
- Routine assessment for biventricular diastolic abnormalities is recommended in pediatric DCM patients.
Abstract:
We evaluated left and right ventricular diastolic functions by pulsed Doppler echocardiography in 16 children with dilated cardiomyopathy and in 20 healthy age-matched control subjects. The cardiomyopathy group demonstrated an abnormal relaxation pattern of the left ventricle. In the cardiomyopathy group compared to normal subjects, peak early filling velocities (43.3 +/- 11 cm/s versus 60.4 +/- 11 cms/s, p < 0.01), the corresponding velocity-time integrals (3.3 +/- 1.4 cm versus 4.6 +/- 1.2 cm, p < 0.01) and the ratio of peak early filling velocity to late filling velocity (1.22 +/- 0.47 versus 1.49 +/- 0.23, p < 0.05) were significantly lower whereas isovolumic relaxation time was significantly longer (58.9 +/- 19.8 ms versus 49.7 +/- 8.9 ms, p < 0.05). In addition, right ventricular diastolic filling was also impaired in children with dilated cardiomyopathy. Peak early filling velocities (41 +/- 7.9 cm/s versus 47.5 +/- 8.8 cm/s, p < 0.05) and the corresponding velocity time integrals (3.0 +/- 1.0 cm versus 3.87 +/- 1.1 cm, p < 0.05) were significantly decreased, while isovolumic relaxation time was significantly increased (60.6 +/- 16.3 ms versus 52.2 +/- 12.8 ms, p < 0.05) in the cardiomyopathy group. The study suggests that abnormalities of both right and left ventricular diastolic function may occur, and should be searched for, in pediatric patients with dilated cardiomyopathy.
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