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Itraconazole oral solution for the treatment of tinea capitis
A K Gupta1, R S Solomon, P Adam
1Department of Medicine, Sunnybrook Health Science Center, Toronto, Ontario, Canada. agupta@execulink.com
Insights
Itraconazole oral solution effectively treated pediatric tinea capitis using pulse therapy. Most children achieved cure with 1-3 pulses, showing good tolerability with minor gastrointestinal effects.
Area of Science:
- Mycology
- Dermatology
- Pediatric Infectious Diseases
Background:
- Tinea capitis is a common fungal infection in children.
- Effective and well-tolerated oral antifungal treatments are needed.
Purpose of the Study:
- To evaluate the efficacy and tolerability of itraconazole oral solution in treating pediatric tinea capitis using pulse therapy.
Main Methods:
- Twenty-seven children received itraconazole oral solution (3 mg/kg/day) in 1-week pulses with drug-free intervals.
- Treatment pulses were administered based on clinical assessment.
- Efficacy and adverse events were monitored.
Main Results:
- 19 evaluable patients showed complete cure after 1-3 pulses, varying by disease severity.
- Mild cases often required one pulse, while severe cases needed three.
- One patient was clinically clear but mycology positive; one discontinued due to nausea.
Conclusions:
- Itraconazole oral solution pulse therapy appears effective and generally well-tolerated for pediatric tinea capitis.
- Further studies with larger patient groups are needed to confirm these preliminary findings.
Abstract:
Twenty-seven children (12 boys, 15 girls, age range 3-11 years, weight range 10-40 kg) were treated with itraconazole oral solution 10 mg/mL given as pulse therapy for tinea capitis. The dosage regimen was 3 mg/kg per day given once daily in a fasting state with each pulse lasting 1 week. The first two pulses were separated by a 2-week off-drug period, and the second and third pulses had a 3-week period without drug between them. For each patient a second and third pulse were administered if there was clinical evidence of tinea capitis at the time-point when the next pulse was due. The overall severity of tinea capitis at pretherapy was classified as mild, moderate or severe with the aetiology being: Trichophyton tonsurans, 24 patients; T. violaceum, two patients and Microsporum canis, one patient. In 19 evaluable patients, 12 weeks after starting therapy, the numbers of pulses of itraconazole oral solution required to produce complete cure were, according to the severity of disease, mild tinea capitis (one pulse: four patients; two pulses: five), moderate disease (one pulse: two patients; two pulses: two; three pulses: two), and severe disease (three pulses: three patients). One patient with moderate severity tinea capitis was clinically clear after three pulses of therapy but mycological examination was positive. Seven patients were lost to follow-up and one discontinued therapy because of nausea. Itraconazole oral solution 3 mg/kg per day was generally well tolerated. Three children developed gastrointestinal adverse effects which were considered to be minor or 'nuisance' effects. The data from this preliminary report need to be confirmed in a larger group of patients. It remains to be seen whether itraconazole oral solution will become a practical alternative to the antifungal agents available in a liquid preparation for the treatment of tinea capitis.