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Related Experiment Videos

Post kala-azar ocular leishmaniasis

A M el Hassan1, E A Khalil, E A el Sheikh

  • 1Institute of Endemic Diseases, University of Khartoum, Sudan.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|October 9, 1998
PubMed
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Post kala-azar ocular leishmaniasis, linked to skin or past visceral leishmaniasis, presents with conjunctivitis, blepharitis, or uveitis. Early diagnosis and treatment with sodium stibogluconate yield good outcomes.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Parasitology

Background:

  • Ocular leishmaniasis can manifest after treatment for visceral leishmaniasis.
  • Eye lesions are often associated with post kala-azar dermal leishmaniasis (PKDL).

Purpose of the Study:

  • To describe the clinical features, diagnosis, and treatment of ocular leishmaniasis in six patients.
  • To highlight the importance of early detection and intervention.

Main Methods:

  • Case series describing clinical presentations.
  • Polymerase chain reaction (PCR) for parasite identification.
  • Diagnosis based on clinical signs, serology, and history of visceral leishmaniasis.

Main Results:

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  • Six patients presented with ocular leishmaniasis, including conjunctivitis, blepharitis, and anterior uveitis.
  • Leishmania donovani was identified in two cases via PCR.
  • All patients responded well to systemic sodium stibogluconate treatment.
  • Anterior uveitis cases also received steroid and atropine eyedrops.

    • Conclusions:

    • Ocular leishmaniasis requires prompt diagnosis and treatment.
    • Systemic sodium stibogluconate is effective, with adjunctive topical therapy for uveitis.
    • Association with PKDL is a key diagnostic clue.