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Related Experiment Videos

Acute stroke following cisplatin therapy

G E Gamble1, P Tyrrell

  • 1Stroke Unit, Department of Geriatric Medicine, Hope Hospital, Salford, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|October 9, 1998
PubMed
Summary
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Cisplatin chemotherapy can cause neurotoxicity and acute stroke. This case study details a young woman experiencing a cerebral infarction, highlighting a potential severe side effect of this cancer treatment.

Area of Science:

  • Oncology
  • Neurology
  • Radiology

Background:

  • Cisplatin is a cornerstone chemotherapy agent with known toxicities.
  • Neurotoxicity is a recognized side effect of cisplatin treatment.
  • A potential link between cisplatin and acute stroke has been suggested.

Observation:

  • A 21-year-old female patient presented with symptoms of an acute stroke.
  • Magnetic Resonance Imaging (MRI) confirmed the diagnosis of cerebral infarction.
  • The patient had a history of receiving cisplatin chemotherapy.

Findings:

  • The case illustrates a rare but serious adverse event associated with cisplatin.
  • Cerebral infarction occurred in a young patient undergoing chemotherapy.
  • Neuroimaging was crucial in diagnosing the stroke.

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Implications:

  • This case underscores the importance of monitoring for neurological complications in patients receiving cisplatin.
  • Further research may be warranted to elucidate the mechanisms linking cisplatin to stroke.
  • Awareness among clinicians regarding this potential side effect is crucial for early detection and management.