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Synthesis of some new biologically active thiadiazolotriazinones
B S Holla1, B K Sarojini, R Gonsalves
1Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, India.
Farmaco (Societa Chimica Italiana : 1989)
|October 9, 1998
Abstract:
4-Amino-6-arylmethyl-3-mercapto-1,2,4-triazin-5(4H)-ones 1 are condensed with aromatic carboxylic acids, aryloxyacetic acids and anilinoacetic acids 2 to yield 7-substituted-3-arylmethyl-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-tr iazin-4-ones 3. Phosphorus oxychloride is used as cyclizing agent. Some of the newly synthesized compounds are screened for their antibacterial activities.