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Synthesis and pharmacological properties of some quinoline derivatives
1Department of Studies in Chemistry, Mangalore University, Karnataka State, India. root@mnglr-ernet.in
Farmaco (Societa Chimica Italiana : 1989)
|October 9, 1998
Abstract:
A series of 2-(2-thienyl) cinchoninic acids 3, their derivatives 5 and 4-(3-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazolo-6-yl)-2-( 2-thienyl) quinolines 6 were synthesized. The structures of the newly synthesized compounds are confirmed by analytical, IR, NMR and mass spectral data. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anthelmintic activity. The results indicated that dinitrothiophene derivatives 5 are more active.