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Serum CA 125 and first trimester abortion

F Scarpellini¹, M Mastrone, M Sbracia

¹II Department of Obstetrics and Gynecology, University of Rome La Sapienza, Italy.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics

|June 1, 1995

Summary

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Serum CA 125, combined with beta-human chorionic gonadotropin (hCG), offers improved prediction of pregnancy outcomes in threatened abortions. This combination aids in assessing the risk of miscarriage during the first trimester.

Area of Science:

Reproductive Endocrinology
Maternal-Fetal Medicine
Clinical Biochemistry

Background:

Early pregnancy complications, such as threatened abortion, require accurate prognostic markers.
Serum biomarkers like CA 125 and beta-human chorionic gonadotropin (hCG) are investigated for their role in predicting pregnancy outcomes.

Purpose of the Study:

To evaluate the clinical utility of serum CA 125, in conjunction with serum beta-hCG, for predicting pregnancy outcomes.
To assess the association between CA 125 levels and tropho-decidual changes in threatened pregnancies.

Main Methods:

A cohort of 100 first-trimester pregnancies, including 48 threatened abortions, were analyzed.
Ultrasound, serum CA 125, and beta-hCG levels were measured and correlated with pregnancy outcomes.

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Main Results:

Threatened pregnancies exhibited significantly higher serum CA 125 levels compared to non-threatened pregnancies.
CA 125 levels positively correlated with tropho-decidual hematoma volume in threatened abortions.
The combined assessment of CA 125 and beta-hCG demonstrated superior prognostic value (sensitivity 78.9%, specificity 96.5%) for pregnancy outcome prediction compared to individual markers.

Conclusions:

The findings support a tropho-decidual origin for serum CA 125.
Serum CA 125, particularly when combined with beta-hCG, shows potential as a valuable prognostic marker for first-trimester threatened abortions.