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Related Experiment Videos

Core variability does not affect response to interferon alpha in HBeAg negative chronic hepatitis B

A Alexopoulou1, A M Owsianka, G Kafiri

  • 1Academic Department of Medicine, Hippokration General Hospital, Athens, Greece.

Journal of Hepatology
|October 9, 1998
PubMed
Summary

Predictors of hepatitis B treatment response were identified. Initial response to alpha-interferon (IFN-alpha) in chronic hepatitis B patients was linked to liver HBcAg absence and high ALT, but sustained response was not predictable.

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Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • The hepatitis B virus (HBV) pre-core stop codon variant (A 1896) is linked to severe chronic liver disease and poor outcomes with alpha-interferon (IFN-alpha) therapy.
  • Mutations in the HBV core region may facilitate immune evasion, contributing to poor sustained responses to IFN-alpha.
  • Identifying predictive factors for IFN-alpha response is crucial for managing chronic hepatitis B.

Purpose of the Study:

  • To analyze predictive factors for response to IFN-alpha therapy in patients with HBV genotype A 1896.
  • To investigate the association between baseline clinical, biochemical, histological, serological, and virological parameters and IFN-alpha treatment outcomes.

Main Methods:

  • Studied 30 HBsAg-positive/HBeAg-negative Greek patients with chronic liver disease treated with IFN-alpha for 24 weeks.

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  • Patients were categorized into non-responders, relapsers, and sustained responders.
  • Analyzed baseline parameters including liver HBcAg staining, ALT levels, and HBV core region amino-acid sequences.

    • Main Results:

    • Initial response to IFN-alpha was predicted by pre-treatment absence of liver HBcAg staining and elevated ALT values.
    • No specific baseline parameter could predict a sustained response to IFN-alpha therapy.
    • The extent and pattern of amino-acid substitutions in the HBV core region were similar across all patient groups and did not correlate with IFN-alpha response.

    Conclusions:

    • In HBsAg-positive/HBeAg-negative patients, IFN-alpha response is not correlated with genomic variability in the HBV core region.
    • Pre-treatment liver HBcAg status and ALT levels are associated with initial response to IFN-alpha.
    • Further research is needed to identify predictors of sustained response in chronic hepatitis B patients.