Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stroke assessment: morphometric infarct size versus neurologic deficit

G M de Courten Myers1, M Kleinholz, K R Wagner

  • 1Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, OH 45267-0529, USA.

Journal of Neuroscience Methods
|October 9, 1998
PubMed
Summary

Histologic infarct size is a more sensitive measure of stroke outcome than neurologic deficit scores in cats. This finding suggests infarct size offers greater statistical power for stroke research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ageing and Mental Health in Canada: Perspectives from Law, Policy, and Longitudinal Research.

Journal of population ageing·2022
Same author

Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Neutrophil to lymphocyte ratio associated with prognosis of lung cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2016
Same author

Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage.

Neuroscience·2014
Same author

Matrix metalloproteinase-2 deletions protect against hemorrhagic transformation after 1 h of cerebral ischemia and 23 h of reperfusion.

Neuroscience·2013
Same author

Matrix metalloproteinase-2 or -9 deletions protect against hemorrhagic transformation during early stage of cerebral ischemia and reperfusion.

Neuroscience·2012

Area of Science:

  • Neuroscience
  • Stroke Research
  • Animal Models

Background:

  • Stroke outcome is typically assessed using neurologic deficits and infarct size.
  • The relative sensitivity of these endpoints in defining stroke outcome requires clarification.

Purpose of the Study:

  • To compare the sensitivity of histologic infarct size and neurologic deficit scores in defining stroke outcome.
  • To determine the statistical power of each endpoint in detecting group differences.

Main Methods:

  • Seventy-six cats underwent middle cerebral artery occlusion.
  • Neurologic deficits were assessed daily using a five-item score.
  • Infarct sizes were determined morphometrically after two weeks.
  • Statistical powers of both endpoints were evaluated using comparison groups.

Related Experiment Videos

Main Results:

  • Neurologic deficit scores correlated well with infarct size (r = 0.76, p < 0.001).
  • Individual deficit components showed decreasing correlation with infarct size.
  • Detecting group differences required twice as many subjects using neurologic deficit scores compared to infarct size.

Conclusions:

  • Histologic infarct size is a more sensitive outcome measure than neurologic deficit assessment in this stroke model.
  • Infarct size provides greater statistical power for stroke outcome studies.