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Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa
K Evans1, L Passador, R Srikumar
1Department of Microbiology and Immunology, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Journal of Bacteriology
|October 10, 1998
Abstract:
Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-1, consistent with an observed reduction in lasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-1-dependent activation of lasI and the virulence genes.