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Related Experiment Videos

Asymptomatic familial cerebral aneurysms

M Kojima1, S Nagasawa, Y E Lee

  • 1Department of Neurosurgery, St. Joseph Hospital for Crippled Children, Kyoto, Japan.

Neurosurgery
|October 10, 1998
PubMed
Summary

The prevalence of cerebral aneurysms is significantly higher in family members of individuals with asymptomatic aneurysms. This suggests a genetic predisposition, particularly in families with a history of aneurysmal subarachnoid hemorrhage.

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Area of Science:

  • Neurology
  • Genetics
  • Vascular Medicine

Background:

  • Cerebral aneurysms affect a significant portion of the population, with rupture leading to subarachnoid hemorrhage.
  • Family history is a known risk factor for cerebral aneurysms, suggesting a potential genetic component.

Purpose of the Study:

  • To determine the prevalence and characteristics of cerebral aneurysms in family members of individuals with asymptomatic aneurysms.
  • To compare aneurysm prevalence in individuals with and without a family history of aneurysms.

Main Methods:

  • Magnetic resonance angiography (MRA) was performed on 8680 participants.
  • Participants were divided into subgroups based on family history of aneurysms.
  • Prevalence and features of asymptomatic aneurysms were analyzed in these subgroups and in 20 specific families.

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Main Results:

  • Overall prevalence of asymptomatic cerebral aneurysms was 7.0%.
  • Participants with a family history of aneurysms had a higher prevalence (10.5%) compared to those without (6.8%).
  • Prevalence was notably higher in females with a family history (12.3%) and specific aneurysm locations (internal carotid-posterior communicating artery, middle cerebral artery) were more common.

Conclusions:

  • A significantly elevated prevalence of cerebral aneurysms exists in family members of individuals with asymptomatic aneurysms.
  • Familial asymptomatic aneurysms may have a higher rupture risk in families with a history of aneurysmal subarachnoid hemorrhage.