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Published on: June 13, 2019
Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review
R Fonseca1, M Yamakawa, S Nakamura
1Division of Hematology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
American Journal of Hematology
|October 10, 1998
Summary
Follicular dendritic cell sarcoma (FDCS) and interdigitating reticulum cell sarcoma (IDCS) are rare neoplasms. IDCS appears more aggressive than FDCS, though diagnosis for both is challenging.
Area of Science:
- Oncology
- Pathology
- Hematology
Background:
- Follicular dendritic cell sarcoma (FDCS) and interdigitating reticulum cell sarcoma (IDCS) are rare neoplasms of reticular dendritic cell origin.
- These conditions present diagnostic challenges requiring comprehensive analysis.
Purpose of the Study:
- To review the literature on FDCS and IDCS.
- To describe clinical observations and pathological features of these rare sarcomas.
Main Methods:
- Computerized database search for published articles on FDCS and IDCS.
- Critical evaluation of retrieved articles.
- Descriptive statistical analysis of collected data.
Main Results:
- The review identified 51 documented cases of FDCS and 21 of IDCS.
- FDCS often presents as lymphadenopathy; extranodal disease and Castleman's disease association noted.
- IDCS typically presents with lymphadenopathy and appears more aggressive than FDCS.
Conclusions:
- Pathologic diagnosis of FDCS and IDCS is challenging, necessitating morphologic, immunophenotypic, cytochemical, and electron-microscopic analysis.
- IDCS exhibits a more aggressive clinical course compared to FDCS.
- The roles of chemotherapy and radiotherapy in managing FDCS and IDCS remain undefined.
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