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Autoimmune progesterone dermatitis: treatment with oophorectomy
J M Ródenas1, M T Herranz, J Tercedor
1Department of Dermatology, Hospital General Universitario Morales Meseguer, Av. Marqués de los Vélez, 30008 Murcia, Spain.
The British Journal of Dermatology
|October 10, 1998
Summary
Autoimmune progesterone dermatitis, a rare hormone hypersensitivity, caused cyclical erythema multiforme in a woman. Oophorectomy provided a cure, demonstrating progesterone
Area of Science:
- Endocrinology
- Dermatology
- Immunology
Background:
- Autoimmune progesterone dermatitis is a rare condition.
- It involves hypersensitivity to endogenous hormones.
- Clinical manifestations are diverse.
Observation:
- A 28-year-old woman presented with a 5-year history of mucocutaneous erythema multiforme.
- Symptoms occurred cyclically, specifically in the premenstrual period.
- Progesterone sensitivity was confirmed via a medroxyprogesterone acetate challenge test.
Findings:
- Various treatments including estrogens, tamoxifen, and triptorelin were ineffective due to adverse effects.
- Surgical removal of the ovaries (oophorectomy) resulted in a complete cure of the condition.
Implications:
- This case highlights oophorectomy as a definitive treatment for severe autoimmune progesterone dermatitis.
- Understanding hormonal triggers is crucial for managing this rare dermatological condition.
- Further research into hormone-mediated dermatoses is warranted.