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Updated: Aug 20, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

Role of spleen in the interferon-lowering action of morphine

W F Geber, S S Lefkowitz, C Y Hung

    General Pharmacology
    |September 1, 1976
    PubMed

    1. Polyinosinie-polycytidylic acid (Poly I:C) administered intraperitioneally to mice produced an increase in the level of interferon in the tissues of the spleen, liver, lung, and kidney. The level of circulating serum interferon also was increased by the polynucleotide. 2. The highest titer of interferon, presumably resulting from the greatest response to poly I:C was measured in the splenic tissue. 3. Morphine inhibited the poly I:C induced increase in all tissues and circulating serum. The decrease in interferon titer was similar in spleen and serum. 4. These results may indicate the serum level of interferon was more closely related and dependent upon events occuring in the spleen than in the other tissues.

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