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Related Experiment Videos

EBV persistence in memory B cells in vivo

G J Babcock1, L L Decker, M Volk

  • 1Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Immunity
|October 13, 1998
PubMed
Summary
This summary is machine-generated.

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Epstein-Barr virus (EBV) persists in resting memory B cells in blood, not all B cells in tonsils. EBV exploits B cell memory mechanisms for long-term persistence.

Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • Epstein-Barr virus (EBV) establishes latency in vitro by activating human B cells into proliferating blasts.
  • In vivo, EBV infection is typically benign, with the virus residing latently in resting B cells in the peripheral blood.

Purpose of the Study:

  • To investigate the specific B cell subset where Epstein-Barr virus (EBV) resides latently in the peripheral blood.
  • To understand the proposed mechanism of EBV persistence by exploiting B cell memory.

Main Methods:

  • Analysis of B cell subsets in peripheral blood and tonsils.
  • Investigation of EBV latency and B cell differentiation pathways.

Main Results:

  • In peripheral blood, EBV latency is restricted to the sIgD memory B cell subset.

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  • In tonsils, EBV shows no such restriction, infecting B cells indiscriminately.
  • Activation to the blastoid stage is an essential intermediate step for EBV latency.

    • Conclusions:

    • EBV infects B cells in mucosal lymphoid tissue, which then differentiate into resting memory B cells entering circulation.
    • EBV persistence is achieved by leveraging the natural mechanisms of B cell memory production and maintenance.