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Association between diet and lung cancer location
B W Lee1, J C Wain, K T Kelsey
1Pulmonary and Critical Care Unit and Thoracic Surgery Unit, Massachusetts General Hospital; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
American Journal of Respiratory and Critical Care Medicine
|October 14, 1998
Summary
Lung cancer is more common in upper lobes. Lower intake of yellow-orange vegetables and vitamin E is linked to upper lobe lung cancer in smokers, suggesting a dietary protective role.
Area of Science:
- Oncology
- Nutritional Epidemiology
- Pulmonary Medicine
Background:
- Lung cancer exhibits a higher incidence in the upper lobes compared to lower lobes, a phenomenon lacking a clear pathophysiological explanation.
- Existing research indicates an inverse correlation between the consumption of specific fruits and vegetables and lung cancer risk.
Purpose of the Study:
- To investigate the association between dietary intake and the location of lung tumors.
- To test the hypothesis that dietary protective factors are less concentrated in upper lung lobes, contributing to tumor predominance in these areas among smokers.
Main Methods:
- A study involving 328 lung cancer patients was conducted to examine diet and tumor location.
- Univariate and multivariable logistic regression analyses were employed to identify predictors of upper lobe tumor location.
Main Results:
- The ratio of upper to lower lobe tumors was 2.5:1.0.
- Independent predictors for upper lobe tumor location included family history of lung cancer, asbestos exposure, lower intake of yellow-orange vegetables, and lower intake of vitamin E.
- A significant inverse association was found between upper lobe lung cancer and the consumption of yellow-orange vegetables and vitamin E.
Conclusions:
- Dietary factors, specifically the intake of yellow-orange vegetables and vitamin E, are significantly associated with the location of lung cancer.
- Reduced intake of these nutrients may contribute to the higher prevalence of lung cancer in the upper lobes, particularly in smokers.