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Local resection after breast-conserving therapy

J Horiguchi1, Y Iino, H Takei

  • 1Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan.

Oncology Reports
|October 14, 1998
PubMed
Summary
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Local re-excision after radiation therapy for breast cancer is effective. In a study of seven patients, only one showed residual carcinoma, demonstrating the procedure

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Positive surgical margins after initial breast-conserving surgery (BCS) necessitate further treatment.
  • Radiation therapy is a standard component of breast cancer management.
  • The role of local re-excision following radiation therapy for positive margins requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of local re-excision after radiation therapy in patients with positive surgical margins from initial BCS.
  • To determine the rate of residual carcinoma in patients undergoing this secondary surgical procedure.

Main Methods:

  • Retrospective analysis of seven patients with positive margins post-BCS and subsequent radiation therapy.
  • Patients underwent local re-excision.

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  • Pathological examination of re-excision specimens to identify residual malignancy.

    • Main Results:

    • One out of seven patients (14.3%) had residual carcinoma identified in the re-excision specimen.
    • Patient demographics included ages 30-55 years and tumor sizes 1.1-4.7 cm.
    • Hormone receptor status varied, with two positive, four negative, and one unknown.

    Conclusions:

    • Local re-excision following radiation therapy appears to be a safe and effective option for managing positive surgical margins in breast-conserving surgery.
    • The low rate of residual carcinoma suggests that radiation may adequately treat microscopic disease in some patients, making re-excision a targeted intervention.