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Related Experiment Videos

Telomerase activity in thyroid tumors

N Onoda1, T Ishikawa, K Yoshikawa

  • 1Department of Oncology, Institute of Geriatrics and Medical Science, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan.

Oncology Reports
|October 14, 1998
PubMed
Summary

Telomerase activity is a potential biomarker for thyroid cancer. This study found telomerase activity in most malignant thyroid tumors and metastatic lesions, correlating with cancer progression.

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Area of Science:

  • Oncology
  • Biochemistry

Background:

  • Telomerase is a key enzyme in cellular immortalization.
  • Its role in thyroid tumorigenesis requires further clinical investigation.

Purpose of the Study:

  • To quantify telomerase activities in thyroid tumors.
  • To determine the clinical significance of telomerase activity in thyroid cancer.

Main Methods:

  • Telomeric-repeat-amplification-protocol (TRAP) based assay was used.
  • Quantification of telomerase activity in malignant and benign thyroid lesions, metastatic tissues, and non-tumoral specimens.

Main Results:

  • Telomerase activity was detected in 55.6% of malignant thyroid tumors, but none of the benign lesions.
  • Activity levels correlated significantly with clinical stage progression.

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  • High telomerase activity was observed in 80% of lymph node metastatic lesions.
  • Telomerase activity was present in 45.5% of non-tumoral specimens from malignant cases.

    • Conclusions:

    • Telomerase activity determination may aid in diagnosing thyroid cancer.
    • It can also be useful for assessing cancer progression and metastasis.