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[Vancomycin-resistant enterococci in pediatric hematology: don't panic!]

G Barbé1, C Ploton, C Pondarré

  • 1Laboratoire de Bactériologie, Faculté de Pharmacie (UPRES-EA 1655), Hôpital Debrousse, Lyon, France.

Pathologie-Biologie
|October 14, 1998
PubMed

Insights

Immunocompromised children carrying vancomycin-resistant enterococci (VRE) may not require eradication treatment. Strict hygiene measures are crucial, as VRE colonization did not lead to bacteremia in this study.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pediatric Oncology

Context:

  • Investigating vancomycin-resistant enterococci (VRE) colonization in immunocompromised children undergoing chemotherapy or bone-marrow transplantation (BMT).
  • Evaluating decontamination protocols including amikacin and vancomycin mouth rinses.
  • Monitoring VRE carriage in a cohort of 230 pediatric patients over three years.

Purpose:

  • To determine if treatment is necessary for immunocompromised children colonized with VRE.
  • To assess the risk of VRE bacteremia in this patient population.
  • To evaluate the efficacy of gut decontamination strategies.

Summary:

  • Four pediatric patients with chemotherapy/BMT were identified as VRE carriers.
  • Fecal VRE carriage was persistent in one patient, with failed eradication attempts.
  • No VRE bacteremia occurred in any of the VRE-colonized patients.

Impact:

  • Suggests that VRE eradication may not be necessary in immunocompromised pediatric patients.
  • Highlights the importance of strict adherence to hygienic measures to prevent VRE complications.
  • Informs clinical decision-making regarding VRE management in vulnerable pediatric populations.

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