Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[p53 and hematologic malignancies]

C Preudhomme1, P Fenaux

  • 1Laboratoire d'Hématologie A, CHRU Hôpital Calmette, Lille, France.

Pathologie-Biologie
|October 14, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[GATA2 gene mutations: 3 cases].

La Revue de medecine interne·2022
Same author

Effects of azacitidine in 93 patients with <i>IDH1/2</i> mutated acute myeloid leukemia/myelodysplastic syndromes: a French retrospective multicenter study.

Leukemia & lymphoma·2020
Same author

Immature platelet fraction (IPF): A reliable tool to predict peripheral thrombocytopenia.

Current research in translational medicine·2019
Same author

Outcomes and mutational analysis of patients with lower-risk non-del5q myelodysplastic syndrome treated with antithymocyte globulin with or without ciclosporine A.

Leukemia research·2018
Same author

Impact of Wilms' tumor 1 expression on outcome of patients undergoing allogeneic stem cell transplantation for AML.

Bone marrow transplantation·2017
Same author

Copy-number analysis identified new prognostic marker in acute myeloid leukemia.

Leukemia·2016
Same journal

Pathologie-biologie·2020
Same journal

Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

Pathologie-biologie·2015
Same journal

[Not Available].

Pathologie-biologie·2015
Same journal

Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol.

Pathologie-biologie·2015
Same journal

Biological diagnosis of diabetes mellitus.

Pathologie-biologie·2015
Same journal

Association of CagPAI integrity with severeness of Helicobacter pylori infection in patients with gastritis.

Pathologie-biologie·2015
See all related articles

p53 gene alterations are less frequent in blood cancers but correlate with poor prognosis. Restoring p53 function may improve chemotherapy sensitivity in these hematological malignancies.

Area of Science:

  • Molecular biology and oncology, focusing on tumor suppressor genes.
  • Hematological malignancies research.

Context:

  • Alterations in the p53 tumor suppressor gene are less common in hematological malignancies (10-15%) compared to solid tumors.
  • p53 gene mutations are typically point mutations, detectable by Single-Strand Conformation Polymorphism (SSCP) or Immunohistochemistry (ICC).
  • A correlation exists between p53 point mutations and positive ICC, except in non-Hodgkin's lymphoma.

Purpose:

  • To investigate the role and characteristics of p53 gene alterations in various hematological malignancies.
  • To correlate p53 gene status with clinical outcomes, including prognosis and chemotherapy resistance.
  • To explore the therapeutic potential of restoring p53 gene function in cancer treatment.

Summary:

  • In myelodysplastic syndromes, acute myeloid leukemia, chronic myeloid leukemia, and chronic lymphoid leukemia, p53 point mutations on one allele are often accompanied by deletion of the other allele, leading to complete p53 gene absence.

Related Experiment Videos

  • This complete absence of p53 is linked to poor prognosis and chemotherapy resistance in these specific leukemias.
  • Conversely, the L3 form of acute lymphoid leukemia and Burkitt's non-Hodgkin's lymphoma exhibit higher frequencies (30%) of p53 point mutations, with rare accompanying 17p deletion.

    • Impact:

    • These findings underscore the critical role of p53 in mediating apoptosis following chemotherapy.
    • The study supports the development of gene therapy strategies aimed at transferring the functional p53 gene into malignant cells.
    • Restoring p53 function holds promise for enhancing chemosensitivity and improving treatment outcomes in patients with hematological malignancies.