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[Aerosols: a re-emerging treatment]

P Diot¹, J P Mallet, E Lemarié

¹Service de Pneumologie, CHU Bretonneau, Tours.

Revue De Pneumologie Clinique

|October 14, 1998

Summary

Aerosol drug delivery effectively treats respiratory diseases like asthma and cystic fibrosis using inhalers and nebulizers. This versatile route shows promise for systemic treatments, including gene therapy and managing conditions like diabetes and pulmonary hypertension.

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Area of Science:

Pulmonary Medicine
Pharmacology
Biotechnology

Context:

Aerosol drug delivery is a crucial administration route for respiratory conditions like asthma and chronic obstructive pulmonary disease.
Metered dose inhalers and dry powder devices enhance patient compliance, while nebulizers serve specific clinical needs.

Purpose:

To review the established and emerging applications of aerosol drug delivery.
To explore the potential of aerosol administration for novel therapies including gene therapy and systemic treatments.

Summary:

Inhaled corticosteroids, beta-2 agonists, and anticholinergic drugs are commonly delivered via aerosols.
Emerging applications include anti-infective agents, rhDNase for cystic fibrosis, nucleotides, antiproteases, and systemic drugs like cyclosporine, prostacyclin, insulin, and morphine.

Impact:

Aerosol therapy offers a minimally invasive and effective method for localized and systemic drug delivery.
The aerosol route is expanding to encompass a wide range of therapeutic targets, improving treatment options for diverse medical conditions.

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