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Updated: Aug 13, 2026
08:40
Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
Targeting DNA methyltransferase in cancer
1Department of Pharmacology, McGill University, Montreal, PQ, Canada. mszyf@pharma.mcgill.ca
Cancer Metastasis Reviews
|October 14, 1998
Summary
DNA methyltransferase enzymes are crucial for DNA methylation patterns, impacting genome function and epigenetic information. Targeting these enzymes in cancer therapy is a promising strategy due to their role in oncogenesis.
Area of Science:
- Epigenetics
- Molecular Biology
- Oncology
Background:
- DNA methyltransferase enzymes are essential for establishing and maintaining DNA methylation patterns.
- DNA methylation is a key epigenetic mechanism regulating genome function.
- Altered DNA methylation patterns are implicated in various cancers.
Purpose of the Study:
- To discuss the potential mechanisms linking DNA methyltransferase activity to cancer development (oncogenesis).
- To explore the rationale for developing DNA methyltransferase inhibitors as a novel anticancer therapy.
Main Methods:
- This is a commentary, not an experimental study. It synthesizes existing research and postulates mechanisms.
- Literature review and theoretical analysis of DNA methyltransferase function in cancer.
Main Results:
- DNA methyltransferase enzymes are increasingly recognized for their significant role in oncogenesis.
- Targeting DNA methyltransferase presents a viable therapeutic strategy for cancer treatment.
Conclusions:
- DNA methyltransferase enzymes are critical players in cancer development.
- Inhibiting DNA methyltransferase offers a promising avenue for innovative anticancer therapies.
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