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Antitumor activity of new derivatives of 1,3-diazaheterocycles
1Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, Poland.
Die Pharmazie
|October 14, 1998
Abstract:
2-Naphthylidene derivatives of 1,3-diazaheterocycles were prepared in order to investigate the relationship between their structure and anticancer activity. Preliminary screening in the standard in vitro assay using 60-tumor cell lines showed that some of these derivatives exhibited a moderate growth inhibition activity on various tumor subpanel cell lines between 10(-6)-10(-4) molar concentration. The results obtained show that the structural features are important in inhibiting tumor cell lines.