Related Experiment Video
Updated: Jul 16, 2026

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
Published on: May 5, 2021
[Participation of glyoxalases and methylglyoxal in diabetic complication development]
D Piskorska1, E Kopieczna-Grzebieniak
1Katedry i Zakładu Biochemii i Chemii Slaskiej Akademii Medycznej w Katowicach.
Abstract:
The glyoxalase system catalyses the conversion of methylglyoxal to D-lactate via intermediate S-D-lactoylgutathione. This system consists of two enzymes, glyoxalase I and glyoxalase II. A link between the development of diabetic complications and the glyoxalase system has been suggested at the genetic and metabolic level. Insulin-dependent diabetic patients without complications (retinopathy, neuropathy) had a significantly higher frequency of the glyoxalase phenotype GLO 1-1 than patients with complications. Periodic hyperglycaemia may contribute to the development of diabetic complication through methylglyoxal-mediated changes in protein solubility and aggregation characteristics.
More Related Videos
06:21Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Type II Diabetes II: Pathophysiology
Complications of Diabetes Mellitus
Hyperglycemia
Diabetic Ketoacidosis ll: Pathophysiology
Diabetic Neuropathy