[In vitro study of the modulating effect of antitubercular agents on the rosette formation response in patients with...

The wide medical application of new highly active antituberculous agents (ATA) having a definite mechanism of action on immunological homeostasis makes pharmacological regulation of immunological responses real in patients with pulmonary tuberculosis. The purpose of this study was to examine the effect of major ATA on the body's immunological responsiveness in vitro, i.e. by the changes in E-RFC used as a loading test, their immunoactive properties were examined with and without addition of ATA. The study provided a new methodological approach which may help in more effectively determining the nature of effects of the study ATA on the qualitative and quantitative parameters of the T system, in clarifying whether ATA have certain immunoregulating properties, and in quantitatively defining the magnitude of their expression. The used parameter E-RFC is an adequate test for studying the immunoactive properties of ATA acting primarily on cell immunity. Thus, this offers scope in practical medicine for goal-oriented regulation of an immune response in different tuberculosis infections by using appropriate ATA.