Modified diagram of Friedman's symbolic representation of cleft lip and palate anomalies

J A Davison1, H Mirlohi, A R Rowsell

  • 1Cleft Palate Unit, Guy's Hospital, London, UK.

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The Frost circle or the inscribed polygon method is a graphical method for determining the relative energies of π molecular orbitals (MOs) for planar, fully conjugated, and monocyclic compounds. This method was first described by A. A. Frost and Boris Musulin in 1953.
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