A frameshift mutation in human MC4R is associated with a dominant form of obesity

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Characterization of lymphocyte profiles in children with syndromic obesity.

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Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance.

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MECHANISMS IN ENDOCRINOLOGY: Update on treatments for patients with genetic obesity.

European journal of endocrinology·2020

Rare genetic forms of obesity: From gene to therapy.

Physiology & behavior·2020

Mechanisms underlying disease-causing variants in promoters and enhancers.

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Cohesin prevents local mixing of condensed euchromatic domains in living human cells.

Nature genetics·2026

Human and mouse adrenal glands are characterized by species-specific steroidogenic states and tissue turnover.

Nature genetics·2026

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility.

Nature genetics·2026

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics.

Nature genetics·2026

Scalable, generalizable and uncertainty-aware integration of spatial multiomics across diverse modalities and platforms with SCIGMA.

Nature genetics·2026

Recent advances in the treatment of chronic liver diseases: focus on MASLD/MASH-related fibrosis.

Clinical and experimental hepatology·2026

Biological age acceleration and extrahepatic multimorbidity in U.S. adults with metabolic dysfunction-associated steatotic liver disease: a national cross-sectional study.

Clinical and experimental hepatology·2026

Plasma Metabolites for Identifying Bacterial Infection in Acute-on-chronic Liver Failure: A Prospective Multicenter Study.

Journal of clinical and translational hepatology·2026

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Comprehensive physiology·2026

AI-driven diagnostic and prognostic models for metabolic dysfunction-associated steatotic liver disease: insights from clinical, imaging, and multi-omics studies-a scoping review.

Frontiers in medicine·2026

Integrative Multi-omics and Machine Learning Reveal the Therapeutic Mechanisms of Juanyu-Xiaozhi Formula in Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatic Fibrosis via the AP-1/PPARγ/SCD1 Axis.

Journal of clinical and translational hepatology·2026

Related Experiment Videos

A frameshift mutation in human MC4R is associated with a dominant form of obesity

Related Concept Videos

An overview of benefits and risks of chronic melanocortin-1 receptor activation.

Characterization of lymphocyte profiles in children with syndromic obesity.

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

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