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Related Experiment Videos

The hormonal response to stress is not modified by the dramatic decrease in prolactin plasma concentration during

R Guieu1, H Dufour, C Devaux

  • 1Laboratoire de Biochimie, Faculté de Médecine Secteur Nord, UMR CNRS, Institut Fédératif J Roche, Marseille, France.

Journal of Neurology, Neurosurgery, and Psychiatry
|October 15, 1998
PubMed
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This summary is machine-generated.

Surgical stress and opiates do not affect prolactin in microprolactinoma patients. Growth hormone (GH) release indicates surgical stress, while beta-endorphin suggests pain response.

Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Surgical Physiology

Background:

  • Microprolactinomas are pituitary tumors affecting prolactin levels.
  • Surgical stress and opiate administration can influence hormonal secretion.
  • Understanding the endocrine response in these patients is crucial for management.

Purpose of the Study:

  • To investigate the endocrine response to surgical stress in women with microprolactinomas.
  • To evaluate the impact of decreased prolactin levels on stress-induced hormone secretion.
  • To examine the effects of exogenous opiates on prolactin secretion.

Main Methods:

  • Analysis of plasma cortisol, prolactin, ACTH, GH, and beta-endorphin like immunoreactivity (beta-ELI).
  • Inclusion of 36 women with microprolactinomas under strict anesthetic and surgical protocols.

Related Experiment Videos

  • Frequent blood sampling (every 10 minutes) from premedication to 3 hours post-induction.

    • Main Results:

    • Prolactin release was not induced by surgical stress or opiate administration in microprolactinoma patients.
    • Reduced prolactin concentrations did not affect the release of other stress-related hormones.
    • An early Growth Hormone (GH) peak was observed, independent of surgical procedure, suggesting GH release due to surgical stress.

    Conclusions:

    • Surgical stress and opiates do not stimulate prolactin secretion in microprolactinoma.
    • The hormonal stress response is not significantly altered by the decrease in prolactin levels.
    • Growth Hormone (GH) may serve as a reliable marker for surgical stress, while beta-endorphin indicates pain.