Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leucocyte ascorbic acid in abnormal leucocyte states

G M Barton, O S Roath

    International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Platelet Aggregation in Primary Raynaud's Phenomenon and the Effect of Enalapril Administration.

    Platelets·2010
    Same author

    Toll-like receptors and their ligands.

    Current topics in microbiology and immunology·2002
    Same author

    Toll-like receptors control activation of adaptive immune responses.

    Nature immunology·2001
    Same author

    TIRAP: an adapter molecule in the Toll signaling pathway.

    Nature immunology·2001
    Same author

    Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands.

    The Journal of experimental medicine·2001
    Same author

    Private psychiatric practice in an era of managed care.

    The Psychiatric clinics of North America·2000
    Same journal

    Fructooligosaccharide Upregulates Colonic Vitamin D Receptors and Modulates Inflammatory Status in High-Fat Diet-Induced Obese Male C57BL/6 Mice.

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition·2026
    Same journal

    Effects of Dietary Peptides From Essence of Chicken on Neuroinflammation and Their Synergism in Neuroprotection.

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition·2026
    Same journal

    The Protective Effect of Vitamin C Targeting Oxidative Stress on Renal Function in Patients with Septic Acute Kidney Injury: A Prospective, Randomized Controlled, Pilot Study.

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition·2026
    Same journal

    Potential Effects of Chia Seed (<i>Salvia</i> <i>hispanica</i> L.) on Adipose Tissue Gene Expression and Obesity Indicators in Cafeteria Diet-Fed Rats.

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition·2026
    Same journal

    Spirulina Supplementation Can Reduce Serum Levels of C-Reactive Protein: A Systematic Review and Meta-Analysis on Randomized Clinical Trials.

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition·2026
    Same journal

    Short-Term Turkish Coffee Consumption Elevates Cardiovascular Risk Markers, Decreases Leptin Levels, and Impairs Sleep Quality in Healthy Young Women: A Pilot Randomized Controlled Trial.

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition·2026
    See all related articles

    Leucocyte ascorbic acid levels are often low in various blood disorders like leukemia and lymphoma. This suggests leucocyte ascorbic acid may not always accurately reflect Vitamin C status in these conditions.

    Area of Science:

    • Hematology
    • Nutritional Biochemistry
    • Oncology

    Background:

    • Leucocyte ascorbic acid (LAA) is a marker for Vitamin C status.
    • Its levels in various hematological conditions are not well-established.
    • Understanding LAA variations is crucial for patient management.

    Purpose of the Study:

    • To investigate LAA levels in patients with diverse leucocyte abnormalities and hematological disorders.
    • To determine if LAA accurately reflects Vitamin C status across these conditions.
    • To explore the relationship between LAA and specific blood cell types.

    Main Methods:

    • Estimation of leucocyte ascorbic acid in patient blood samples.
    • Comparison of LAA levels with normal ranges in various hematological conditions.

    Related Experiment Videos

  • Analysis of LAA levels in relation to specific diagnoses and treatments.

    • Main Results:

    • Subnormal LAA levels were observed in chronic myeloid leukemia, chronic lymphatic leukemia, acute leukemias, lymphomas, and myelofibrosis.
    • Lower LAA levels were also noted in patients on cytotoxic drugs, with polymorph leucocytosis, purpura, and in pregnant women.
    • Normal LAA levels were typical in anemia (normal leucocyte count) and myelomatosis.
    • LAA levels were found to be primarily associated with mature polymorphonuclear leukocytes.

    Conclusions:

    • LAA is frequently subnormal in various hematological malignancies and conditions.
    • LAA may not be a reliable indicator of Vitamin C status in patients with leucocyte disorders.
    • Mature polymorphs appear to be the main carriers of LAA.