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Primate antisaccades. I. Behavioral characteristics

N Amador1, M Schlag-Rey, J Schlag

  • 1Department of Neurobiology and Brain Research Institute, University of California at Los Angeles School of Medicine, Los Angeles, California 90095-1763, USA.

Journal of Neurophysiology
|October 17, 1998
PubMed
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This study successfully trained monkeys to perform antisaccade tasks, a complex eye movement requiring opposite saccades to a stimulus. While monkeys showed similar accuracy and velocity to prosaccades, their reaction times varied, highlighting differences from human performance.

Area of Science:

  • Neuroscience
  • Primate Behavior
  • Ophthalmology

Background:

  • The antisaccade task, crucial for studying executive control and frontal lobe function, involves directing eye movements away from a stimulus.
  • Previous attempts to train non-human primates on antisaccade tasks were limited, hindering comparative studies with humans.

Purpose of the Study:

  • To establish and characterize a subhuman primate model for antisaccade (AS) performance.
  • To compare the accuracy, velocity, and latency of AS with prosaccades (PS) in monkeys.
  • To investigate potential differences in AS performance between monkeys and humans.

Main Methods:

  • Monkeys were trained on an antisaccade task with randomized pro- and antisaccade cues and peripheral stimuli.
  • Data from 7,430 pro-/antisaccades were analyzed from an "immediate saccade" task version.

Related Experiment Videos

  • Key metrics including accuracy, velocity, and reaction time were compared between prosaccades and antisaccades.

    • Main Results:

    • Antisaccades were significantly less accurate and slower than prosaccades in both monkeys.
    • Error rates for antisaccades were approximately 25%.
    • Reaction times showed inter-monkey variability, with one exhibiting longer latencies for antisaccades, aligning partially with human data.

    Conclusions:

    • This study demonstrates the feasibility of a subhuman primate model for antisaccade performance.
    • The findings suggest irreducible differences in antisaccade execution between humans and monkeys.
    • The model provides a foundation for further research into the neural mechanisms of antisaccade control.