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Concomitant vaccination against hepatitis A and typhoid fever
C Van Hoecke1, E Lebacq, J Beran
1SmithKline Beecham Biologicals, Rixensart, Belgium.
Journal of Travel Medicine
|October 17, 1998
Summary
This study found that combining hepatitis A and typhoid vaccines is safe and effective. Simultaneous administration, whether mixed or separate, did not impact immune responses or cause significant side effects.
Area of Science:
- Immunology
- Vaccinology
- Public Health
Background:
- Simultaneous vaccination strategies are crucial for efficient disease prevention.
- Evaluating the safety and immunogenicity of combined vaccines is essential.
Purpose of the Study:
- To assess the reactogenicity and immunogenicity of a hepatitis A vaccine (Havrix-1440TM) when given with a Vi polysaccharide typhoid vaccine.
- To determine if simultaneous administration affects vaccine efficacy or safety.
Main Methods:
- Two randomized studies were conducted in Belgium and the Czech Republic with healthy adults aged 18-50.
- Vaccines were administered concomitantly, mixed extemporaneously, or as single vaccines.
- Reactogenicity was monitored for 28 days, and antibody titers (anti-HAV and anti-Vi) were measured pre- and post-vaccination.
Main Results:
- Most local and general symptoms were mild to moderate and resolved without sequelae.
- No serious adverse events were reported in either study.
- Geometric mean antibody titers (GMTs) and seroconversion rates (>94.4%) were comparable across all administration methods, indicating no significant cross-interference.
Conclusions:
- Inactivated hepatitis A and Vi polysaccharide typhoid vaccines are safe and well-tolerated when administered simultaneously.
- Combined administration does not compromise the immune response to either vaccine.
- These findings support the use of combined hepatitis A and typhoid vaccination for improved public health outcomes.