Related Experiment Videos
[Mulivariate analysis of prognostic factors in non-small cell lung cancer]
Objectives:
To find independent prognostic factor of non-small cell lung cancer (NSCLC), identify the population with "high-risk" of recurrence and death in resected NSCLC, and direct adjuvant therapy for clinical doctors.
Methods:
85 resected patients from NSCLC were followed up. All patients were subjected to the study by light microscope, immunochemistry, PCR-SSCP method, and DNA image analysis. Thirteen clinical, pathological, and biological factors were analysed by Cox regression model.
Results:
The median follow-up period was 47 months. The overall 3-year survival rate was 66% and the overall 5-year survival rate 61%. Cox regression showed significant univariate predictors (P < 0.05) of early recurrence and death for NSCLC were lymphnode status, pTNM, tumor emboli, microvessel count, Ki-67 antigen labeling, DNA relative content and p53 gene mutation. Microvessel count (P < 0.001) and pTNM (P = 0.006) were independent predictors of early recurrence and cancer-death. According to the multivariate model for predicting early recurrence and cancer death, prognostic index (PI) was calculated.
Conclusion:
The PI may be a useful clinical tool for evaluating prognosis of patients and identifying the population with "high-risk" of recurrence and death in NSCLC.