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Related Experiment Videos

Marked individual variability in heart rate "normalization" by ethanol

T E Reed

    Psychopharmacology
    |June 15, 1978
    PubMed
    Summary
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    Ethanol "normalization" reduces extreme heart rates in both mice and humans. This effect, observed in non-alcoholics, shows significant individual variability and may relate to alcoholism predisposition.

    Area of Science:

    • Psychopharmacology
    • Behavioral Neuroscience

    Background:

    • Kissin's concept of "normalization" by ethanol describes how deviant pre-alcohol physiological parameter values become less deviant after alcohol consumption.
    • This phenomenon was initially observed in alcoholics.

    Purpose of the Study:

    • To test Kissin's "normalization" concept in non-alcoholic subjects using heart rate (HR) data.
    • To investigate ethanol's effect on normalizing deviant HR in both mice and humans.

    Main Methods:

    • Analysis of heart rate data from 1055 unselected mice and 24 non-alcoholic young adults.
    • HR was measured before and after ethanol administration (mice: 1.4g/kg, i.p.; humans: 1.3g/kg, oral).

    Main Results:

    • Both mice and humans exhibited average "normalization" of HR, with initially low HR increasing and initially high HR decreasing post-ethanol.

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  • Strong negative correlations were found between pre-alcohol HR deviation and post-ethanol HR change (-0.803 for mice, -0.538 for humans).
  • Significant individual variability in the normalization response was observed.

    • Conclusions:

    • Ethanol-induced "normalization" of psychophysiological parameters, like heart rate, occurs in non-alcoholic humans and mice, not just alcoholics.
    • The individual variability in this normalizing response suggests potential implications for alcoholism predisposition, though further research is needed.