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[The renal function protection of prostaglandin E1 from hemolysis caused by cardiopulmonary bypass]
1Cardiovascular Surgical Department, 1st Affiliated Hospital, China Medical University.
Objective:
To observe the renal function protection of PGE1 from hemolysis caused by CPB during and after CPB.
Method:
F-Hb in blood, NAG & beta 2-MG in urine were measured in twenty patients who underwent valvular replacement operation. The patients were divided into two groups at random. The PGE1 group was administered of PGE1 with the dose of 100 ng/kg.min for 30' before CPB, 30 ng/kg.min during CPB intravenation and 100 ng/ml before CPB in CPB mechanical equipment. The control group was administered of N. S.
Results:
After termination of CPB, F-Hb rose continuously, showing that the damaging RBC factors did not stop working at once after CPB. F-Hb and beta 2-MG were positively correlated and F-Hb and NAG/Cr were positively correlated, demonstrating that increased F-Hb is an important factor for renal function damage. At 60 minutes after CPB and 120 minutes after CPB, F-Hb values of PGE1 group were significantly lower than those of the control group. beta 2-MG and NAG/Cr of the PGE1 group also showed the same trend. The peak of the control group F-Hb was later than that of the PGE1 group.
Conclusions:
The results demonstrate that PGE1 can protect renal function by decreasing F-Hb level during CPB and shortening the time of hemolysis after CPB.