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[Studies on metabolism of 6-methoxy butyl phthalide by rat liver microsomes]
1Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1996
Abstract:
The in vitro biotransformation of 6-methoxy butyl phthalide (MBP) by phenobarbital induced rat liver microsomes was investigated by GC/MS and GC/MS with TMS derivatization. Three major metabolites of MBP were identified as 3-OH-MBP, 6-OH-butyl phthalide and gamma-OH-MBP. A less polar metabolite was tentatively identified as an epoxidation product.