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[Heart rate and sympathetic risk]
1CHU, Grenoble.
Annales De Cardiologie Et D'Angeiologie
|October 17, 1998
Insights
Elevated heart rate (HR) is linked to cardiovascular risk through sympathetic nervous system activation. However, prospective studies are needed to confirm HR as a primary cardiovascular endpoint.
Area of Science:
- Cardiology
- Epidemiology
- Physiology
Context:
- Retrospective studies suggest elevated heart rate (HR) is a significant cardiovascular risk factor.
- Sympathetic nervous system activation is implicated in HR-related cardiovascular complications.
Purpose:
- To review existing evidence linking heart rate to cardiovascular risk.
- To highlight the need for prospective epidemiological studies with heart rate as a primary endpoint.
Summary:
- Elevated HR predicts cardiovascular risk by activating the sympathetic system, increasing blood pressure, and promoting atherosclerosis.
- Existing evidence is largely retrospective, necessitating prospective research.
Impact:
- This review underscores the importance of considering heart rate in cardiovascular risk assessment.
- It calls for future research to prospectively validate HR as a primary cardiovascular endpoint.
Abstract:
A number of retrospective epidemiological and clinical arguments described in this article demonstrate that elevated heart rate (HR) is a predictive factor of cardiovascular risk due to activation of the sympathetic system which increases blood pressure and increases the risk of atherosclerosis and its complications. However, no epidemiological study has prospectively studied HR as the primary endpoint.