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[Lead intoxication and amyotrophic lateral sclerosis]

P Couratier1, P Bernet-Bernady, T Truong

  • 1Service de Neurologie, CHU Dupuytren, Limoges.

Revue Neurologique
|October 17, 1998
PubMed
Summary

Chronic lead intoxication from drinking water may cause bulbar amyotrophic lateral sclerosis. Six months of 2,3 dimercaptosuccinic acid treatment did not alter the disease

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Area of Science:

  • Neurology
  • Toxicology
  • Environmental Health

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Environmental toxins are implicated in some neurodegenerative conditions.

Observation:

  • A seventy-six-year-old patient presented with bulbar-onset amyotrophic lateral sclerosis.
  • The patient had a history of chronic lead intoxication linked to contaminated drinking water.

Findings:

  • Treatment with 2,3 dimercaptosuccinic acid (DMSA) for six months showed no improvement in the patient's clinical progression.
  • This case suggests a potential etiological role for lead in the development of ALS.

Implications:

  • Highlights the neurotoxic potential of chronic lead exposure.

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  • Suggests further research into environmental factors contributing to amyotrophic lateral sclerosis.
  • Underscores the need for vigilance in identifying and mitigating environmental causes of neurological diseases.