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[Pharmacologic approach to autonomic failure]

J M Senard1, J L Montastruc

  • 1Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 317, Faculté de Médecine, Toulouse, France.

Therapie
|October 17, 1998
PubMed
Summary

This review explores the pharmacology of primary autonomic failure, detailing mechanisms and treatments for orthostatic hypotension. It covers drug efficacy and side effects for managing this disabling symptom.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Autonomic Nervous System Disorders

Context:

  • Primary autonomic failure encompasses multiple system atrophy, pure autonomic failure, Parkinson's disease, and dopamine beta-hydroxylase deficiency.
  • Understanding the pathophysiology of autonomic dysfunction is crucial for effective treatment.

Purpose:

  • To elucidate the pathophysiological mechanisms of autonomic failure at central, presynaptic, and postsynaptic levels.
  • To discuss the efficacy and side effects of pharmacological treatments for orthostatic hypotension in autonomic failure.

Summary:

  • Investigates central (growth hormone response), presynaptic (catecholamines), and postsynaptic (receptor binding) mechanisms in autonomic failure.
  • Reviews drugs targeting blood composition (fludrocortisone, erythropoietin), alpha-adrenoceptors (midodrine, clonidine), and noradrenaline (yohimbine, L-Threo-DOPS) for orthostatic hypotension.

Impact:

  • Provides insights into the pharmacological basis of autonomic failure.
  • Offers guidance on managing orthostatic hypotension, a key disabling symptom.

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